Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbb-2 in human gastric cancer
作者： Akira Tokunaga , Masahiko Onda , Takeshi Okuda , Tadashi Teramoto , Itsuo Fujita
DOI: 10.1002/1097-0142(19950315)75:6+<1418::AID-CNCR2820751505>3.0.CO;2-Y
关键词: Heparin-binding EGF-like growth factor 、 Internal medicine 、 Cancer 、 Metastasis 、 Neoplastic cell 、 Epidermal growth factor 、 Medicine 、 Monoclonal antibody 、 Autocrine signalling 、 Endocrinology 、 Receptor 、 Cancer research 、 Oncology
摘要: The EGF stimulation system for growth regulation is implicated in normal and neoplastic cell proliferation. role of EGF, the receptor, c-erbB-2 human gastric cancer reviewed on basis several reports, which have been mainly oriented toward their clinical significance. has shown immunohistochemically to be present 26% cancers (n = 395). presence correlated with degree wall invasion lymph node metastasis. 5-year survival patients EGF-positive tumors worse than that EGF-negative tumors. may therefore represent a higher malignant potential. Fifteen percent 352) were also positive both receptor immunohistochemically, simultaneous occurrence suggests these grow an autocrine fashion. Tumors exhibiting simultaneously show greater local Increased expression protein appears related biologic aggressiveness, although gene amplification occurred only small extent. Twelve 486) found c-erbB-2. This type tumor frequent metastasis, c-erbB-2-positive poorer prognosis those c-erbB-2-negative Selective blockade from ligands monoclonal antibodies (MoAbs) inhibits xenografts. These MoAbs effective antitumor agents against showing overexpression receptors or
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