Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: an in vivo study.

摘要: The purpose of this study was to evaluate the strontium-containing hydroxyapatite (Sr-HA) cement in primary hip replacement, using a rabbit model, and investigate histological findings at cement–implant bone–cement interfaces under weight-bearing conditions. Unilateral replacement performed with Sr-HA or polymethylmethacrylate (PMMA) rabbits observations were made after 6 months. Good fixation between implant observed. Osseointegration cancellous bone widespread. Many multinucleus cells covered surface cement, resorbed superficial layer cement. By scanning electron microscopy (SEM) energy-dispersive X-ray (EDX) analysis, high calcium phosphorus levels detected interface thickness about 10 μm. Intimate contact also observed cortical without fibrous intervening. overall affinity index on (85.06 ± 5.40)%, which is significantly higher than that PMMA (2.77%± 0.49%). On contrary, consistently bone, evoked an inflammatory response foreign body reaction surrounding bony tissues. Results suggested good bioactivity bone-bonding ability © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006