Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites.
作者： KL Wong , CT Wong , WC Liu , HB Pan , MK Fong
DOI: 10.1016/J.BIOMATERIALS.2009.04.016
关键词:
摘要: Strontium-containing hydroxyapatite/polyetheretherketone (Sr-HA/PEEK) composites were developed as alternative materials for load-bearing orthopaedic applications. The amount of strontium-containing hydroxyapatite (Sr-HA) incorporated into polyetheretherketone (PEEK) polymer matrix ranged from 15 to 30 vol% and the successfully fabricated by compression molding technique. This study presents mechanical properties in vitro human osteoblast-like cell (MG-63) response composite material developed. bending modulus strength Sr-HA/PEEK tailored mimic cortical bone. PEEK reinforced with 25 Sr-HA exhibited 9.6 10.6 GPa, respectively; alternatively, strengths 93.8 89.1 MPa, respectively. Based on qualitative comparison apatite formation SBF quantitative measurement MG-63-mediated mineralization vitro, was proven outperform HA/PEEK providing bioactivity. However, no difference found trend proliferation alkaline phosphatase activity between different composites. Strontium, form (Sr-HA), confirmed enhance bioactivity
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