SCAMP 37, a new marker within the general cell surface recycling system.

摘要: Secretory carrier membrane proteins (SCAMPs) are widely distributed as components of post-Golgi membranes that function recycling carriers to the cell surface. In fibroblasts, SCAMPs concentrated in compartments involved endocytosis and surface receptors while neurons other types having regulated transport pathways, also (synaptic vesicles, secretion granules transporter vesicles). Their presence multiple pathways distinguishes them from (e.g. synaptic vesicle proteins) which selected pathways. The do not appear reside beyond boundaries these This distribution suggests general markers recycling. primary sequence SCAMP 37 reveals a novel polypeptide containing series structural motifs, including calcium binding domain, leucine zipper two zinc fingers. very broad tissue distribution, subcellular localization analysis all predict play fundamental role