Effect of baclofen on oesophageal motility and transient lower oesophageal sphincter relaxations in GORD patients: a 48-h manometric study.
作者： l. grossi , m. spezzaferro , l. f. sacco , l. marzio
DOI: 10.1111/J.1365-2982.2008.01115.X
关键词: Therapeutic effect 、 Gastroenterology 、 Reflux 、 Anesthesia 、 Placebo 、 Baclofen 、 Peristalsis 、 Basal (phylogenetics) 、 Internal medicine 、 Concomitant 、 Motility 、 Medicine
摘要: Little is known about prolonged effect of baclofen on oesophageal and lower sphincter (LOS) motility. We aimed at investigating the motility in gastro-oesophageal reflux disease (GORD) patients 24 h before after administration multiple doses baclofen. Twenty-one GORD underwent a 48-h manometry recording swallows, LOS During second 24-h period, received 10 mg or placebo four times per day double-blind randomized fashion. Baclofen increased basal tone comparison with baseline (P = 0.02), concomitant reduction number transient relaxations (TLOSRs) 0.01). Moreover, induced decrease swallows 0.02) primary body waves 0.04) no changes amplitude. Multiple determine TLOSRs an increase throughout h. The decreased peristalsis could depend well-known amount episodes by drug. potential therapeutic be expressed not only postprandially, but also fasting state when are present as well.
sci-hub.se 参考文章(25)
E. W. Wuis, M. J. M. Dirks, T. B. Vree, E. Van der Kleijn, Pharmacokinetics of baclofen in spastic patients receiving multiple oral doses. Pharmacy World & Science. ,vol. 12, pp. 71- 74 ,(1990) , 10.1007/BF01970149
Daniel Sifrim, Richard H Holloway, Jan Tack, Adriana Zelter, Tom Missotten, Bernard Coulie, Jozef Janssens, Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects. The American Journal of Gastroenterology. ,vol. 94, pp. 3158- 3164 ,(1999) , 10.1111/J.1572-0241.1999.01509.X
R Penagini, PA Bianchi, Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation Gastroenterology. ,vol. 113, pp. 409- 414 ,(1997) , 10.1053/GAST.1997.V113.PM9247457
Ravinder K. Mittal, Richard H. Holloway, Roberto Penagini, L. Ashley Blackshaw, John Dent, Transient lower esophageal sphincter relaxation Gastroenterology. ,vol. 109, pp. 601- 610 ,(1995) , 10.1016/0016-5085(95)90351-8
Ravinder K. Mittal, Richard Holloway, John Dent, Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects Gastroenterology. ,vol. 109, pp. 1547- 1554 ,(1995) , 10.1016/0016-5085(95)90643-6
r. c. h. scheffer, e. b. wassenaar, m. a. herwaarden, r. h. holloway, m. samsom, a. j. p. m. smout, l. m. a. akkermans, Relationship between the mechanism of gastro‐oesophageal reflux and oesophageal acid exposure in patients with reflux disease Neurogastroenterology and Motility. ,vol. 17, pp. 654- 662 ,(2005) , 10.1111/J.1365-2982.2005.00686.X
J. W. A. Straathof, M. Luchtenborg, A. A. M. Masclee, Comparison of two techniques for lower oesophageal sphincter manometry: sleeve and sphinctometer. Neurogastroenterology and Motility. ,vol. 16, pp. 265- 268 ,(2004) , 10.1111/J.1365-2982.2004.00500.X
Anders Lehmann, Marianne Bremner-Danielsen, Lena Brändén, Lillevi Kärrberg, Inhibitory effects of GABAB receptor agonists on swallowing in the dog European Journal of Pharmacology. ,vol. 448, pp. 67- 70 ,(2002) , 10.1016/S0014-2999(02)01907-6
R. H. Holloway, P. Kocyan, J. Dent, Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastroesophageal reflux Digestive Diseases and Sciences. ,vol. 36, pp. 1034- 1039 ,(1991) , 10.1007/BF01297443
A F Ciccaglione, Effect of acute and chronic administration of the GABAB agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease Gut. ,vol. 52, pp. 464- 470 ,(2003) , 10.1136/GUT.52.4.464