Can tissue oxygenation index (TOI) and cotside neurophysiological variables predict outcome in depressed/asphyxiated newborn infants?

摘要: Abstract Background Diagnostic tools of birth asphyxia provide only an uncertain prediction neurological outcome. Aims To assess whether TOI and ΔCBV, combined with a set biochemical neurophysiological variables, have any diagnostic prognostic value in depression or asphyxia. Study design Case control study at the nursery NICU Padova University Children's Hospital. Subjects 22 term neonates Apgar score ≤ 6 5′, 1-h umbilical artery pH ≤ 7.25 increased base deficit gestational age ≥ 36 weeks; 15 healthy infants ≥ 9 5′. Outcome measures Troponin I NIRS measurements (TOI ΔCBV) were assessed both groups. Blood gases, evaluation, US, NIRS, EEG SEP evaluated Results was higher group than controls ( p  = 0.04), showing correlation excess values. In depressed/asphyxiated abnormal outcome 1 year, rose to 80.1% vs 66.4%  = 0.04) 74.7% normal 1-year A multiple regression model showed significant coefficient, R  = 0.79, Conclusions is useful short-term index perinatal depression. An suggests risk 1 year. Among cotside BE evoked potential abnormalities best predictors this study.