Minimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer.

摘要: Background The purpose of this study was to investigate whether the minimum absolute lymphocyte count (ALC) during radiotherapy (RT) could predict clinical outcome in patients with nasopharyngeal cancer (NPC). Methods We analyzed 70 NPC including 63 treated chemoradiotherapy and used multivariate analysis determine ALC affected outcome. Results Patients were grouped by ALC, a cutoff 245 cells/μL. Five-year disease-specific survival (DSS) progression-free (PFS) for ≥245 versus <245 88.1% 60.8% (p = .004) 71.2% 35.2% .004). All 10 <120 experienced disease progression. Four 6 (67%) who died progression within months. Conclusion Minimum may poor 5-year DSS should be evaluated prospective studies. © 2015 Wiley Periodicals, Inc. Head Neck,