Dosimetric Predictors of Treatment-related Lymphopenia induced by Palliative Radiotherapy: Predictive Ability of Dose-volume Parameters based on Body Surface Contour.

摘要: @font-face { font-family: "Arial"; }@font-face "ＭＳ 明朝"; "Cambria Math"; "@ＭＳ "MS ??"; "Calibri"; "@MS }p.MsoNormal, li.MsoNormal, div.MsoNormal margin: 0mm 0.0001pt; font-size: 12pt; "Times New Roman"; }p.Default, li.Default, div.Default Calibri; color: black; }.MsoChpDefault 10pt; }div.WordSection1 } Background. Radiation-related lymphopenia has been associated with poor patient outcome. We sought to identify predictors of after palliative radiotherapy, a focus on dose-volume parameters. Materials and methods. To retrospectively assess patients various cancers who had undergone we delineated three organs at risk: the volume enclosed by body surface contour (body A), left excluding air, pleural effusion, ascites, bile, urine, intestinal content B), bone marrow (BM). then noted absolute risk that received 5 - 30 Gy, assessed predictive value for post-treatment grade 3 or higher (LP3+). Results. Of 54 patients, 23 (43%) developed LP3+. Univariate logistic regression analysis showed A V5, V10, B number fractions, splenic irradiation were significant LP3+ (p < 0.05). By multivariate analysis, fractions retained significance BM parameters did not predict lymphopenia. Conclusions. Higher larger may be severe radiotherapy.