Distribution Atlas of Proliferating Bone Marrow in Non-Small Cell Lung Cancer Patients Measured by FLT-PET/CT Imaging, With Potential Applicability in Radiation Therapy Planning

摘要: Purpose Proliferating bone marrow is exquisitely sensitive to ionizing radiation. Knowledge of its distribution could improve radiation therapy planning minimize unnecessary exposure and avoid consequential prolonged myelosuppression. [18F]-Fluoro-3-deoxy-3-L-fluorothymidine (FLT)–positron emission tomography (PET) a novel imaging modality that provides detailed quantitative images proliferating tissues, including marrow. We used FLT-PET imaging in cancer patients produce an atlas with potential clinical utility. Methods Materials The fused CT scans eligible non-small cell lung (no distant metastases, no prior cytotoxic exposure, hematologic disorders) were reviewed. proportions skeletal FLT activity 10 predefined bony regions determined compared according age, sex, recent smoking status. Results Fifty-one studied: 67% male; median age 68 (range, 31-87) years; 8% never smokers; 70% the preceding 3 months. Significant differences occurred between sex groups. No effect was detected from Using mean percentages uptake per body region, we created functional 4 subgroups defined by age. Conclusions This has utility for estimating active adult guide planning. However, because interindividual variation it should be caution when risks ablating large marrow; such cases, individual may required.