Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.
作者： Ho Sik Rho , Soo Mi Ahn , Dae Sung Yoo , Myung Kyoo Kim , Dong Ha Cho
DOI: 10.1016/J.BMCL.2010.09.042
关键词: Sulfone 、 Chemistry 、 Sulfoxide 、 Stereochemistry 、 Moiety 、 Alkyl 、 Anti-inflammatory 、 Tyrosinase 、 Kojic acid 、 Thioether
摘要: This study was conducted to examine the tyrosinase inhibitory and anti-inflammatory activities of kojic acid derivatives. A series derivatives containing thioether, sulfoxide, sulfone linkages were synthesized. In assay, kojyl thioether appropriate lipophilic alkyl chains (pentane, hexane, cyclohexane) showed potent activity. However, sulfoxides sulfones exhibited decreased Similar experimental results obtained with NO production being induced by LPS. The presence linkage appropriated moiety critical for activities.
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