Block of the Rapid Component of the Delayed Rectifier Potassium Current by the Prokinetic Agent Cisapride Underlies Drug-Related Lengthening of the QT Interval
作者： Benoit Drolet , Majed Khalifa , Pascal Daleau , Bettina A. Hamelin , Jacques Turgeon
关键词: Prokinetic agent 、 Repolarization 、 QT interval 、 Cisapride 、 Myocyte 、 Heart block 、 Electrophysiology 、 Pharmacology 、 Medicine 、 Torsades de pointes
摘要: Background—Lengthening of the QT interval and torsades de pointes resulting in cardiac arrests deaths have been noticed during treatment with cisapride, a newly developed gastrointestinal prokinetic agent. The rapid (IKr) slow (IKs) components delayed rectifier current (IK) are candidate ionic currents to explain cisapride-related toxicity because their role repolarization ventricular myocytes. Our objectives were (1) characterize effects cisapride on two major time-dependent outward potassium involved myocytes, IKr IKs, (2) determine action potential–prolonging isolated hearts. Methods Results—A first set experiments was performed guinea pig myocytes whole-cell configuration patch-clamp technique. Cells held at −40 mV while elicited by depolarizing pulses lasting either 250 ms (IK250) or 5000 ms...
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