Meeting Highlights: International Expert Consensus on the Primary Therapy of Early Breast Cancer 2005

摘要: The ninth St Gallen (Switzerland) expert consensus meeting in January 2005 made a fundamental change the algorithm for selection of adjuvant systemic therapy early breast cancer. Rather than earlier approach commencing with risk assessment, Panel affirmed that first consideration was endocrine responsiveness. Three categories were acknowledged: responsive, non-responsive and tumors uncertain three further divided according to menopausal status. Only then did divide patients into low-, intermediate- high-risk categories. It agreed axillary lymph node involvement not automatically define high risk. Intermediate included both node-negative disease (if some features primary tumor indicated elevated risk) one involved nodes without additional such as HER2/neu gene overexpression. recommended be offered chemotherapy nonresponsive disease; responsive disease, adding all groups this category; response category except those low-risk group.