Peptide-based vaccines in breast cancer.

摘要: Human tumors are immunogenic and tumor-associated proteins that generate immunity in cancer patients have been defined. Many of these involved the malignant transformation play a role either initiating or maintaining phenotype. Furthermore, due to technical advances basic immunology over last decade we better understanding immune effector cell phenotypes potentially tumor eradication developed methods quantitate characterize effectors. Breast is an intriguing model target with ac- tive immunization. Dozens breast antigens defined (1). Although many can be rendered free disease standard therapy such as surgery, radiation, chemotherapy, some will their recur. However, relapse may not occur for months years after definitive treatment giving extended period micrometastatic amenable modulation. Peptide based vaccines one most commonly studied vaccine strategies targeting cancer. Abbreviations: APC: antigen presenting cell; CEA: carcinoembryonic antigen; CTL: cytotoxic T DC: dendritic ECD: extracellular domain; GM-CSF: granulocyte macrophage colony stimulating factor; HLA: human leukocyte IFA: incomplete Freund's adjuvant; IFN: interferon; IL: interleukin; KLH: keyhole limpit hemocyanigen; LC: Langerhans' MHC: major histocompatibility PBMC: peripheral blood mononuclear cells; TCR: receptor; Th: helper