TCR γδ bearing T lymphocytes infiltrating human primary cutaneous melanomas

摘要: Abstract In situ immunophenotypic studies show that tumor infiltrating T lymphocytes from six of 11 fresh cutaneous primary melanomas tested contain T-cell receptor γδ expressing cells whereas those 8 metastatic did not. three cases these represent an unexpectedly high proportion the lymphocytic infiltrate, ranging 15 to 25%. This elevated percentage is maintained when are propagated in vitro for 2 or 3 weeks presence recombinant interleukin and autologous cells. Functional reveal lines clones developed melanoma display, addition their natural killer- like activity, a potent cell cytotoxic activity does not seem be restricted by major histocompatibility complex gene products.