Murine double minute 2promoter SNP309 polymorphism and prostate cancer risk: A meta-analysis
作者： Guoyuan Liu , Deke Jiang , Suqin Shen , Long Yu
DOI: 10.1111/J.1442-2042.2012.03067.X
关键词: Medicine 、 Carcinogenesis 、 Allele 、 Bioinformatics 、 Confidence interval 、 Meta-analysis 、 Single-nucleotide polymorphism 、 Odds ratio 、 Internal medicine 、 Oncology 、 Prostate cancer 、 Genetic model
摘要: Objective: The murine double minute 2 gene encodes a negative regulator of the tumor protein p53. A single nucleotide polymorphism in promoter, SNP309 T>G, has been reported to alter expression and accelerate formation humans. We carried out meta-analysis explore association between this prostate cancer risk. Methods: All eligible studies were searched PubMed. Crude odds ratios, with 95% confidence intervals, assessed for using fixed- random-effects models. Results: Overall, five case–control (872 cases, 1005 controls) included meta-analysis. significant risk was observed homozygote genetic model GG versus TT (odds ratio 0.72, interval 0.55–0.95, P < 0.05, P = 0.130 heterogeneity), dominant TG + GG 0.79, 0.65–0.96, P = 0.119 heterogeneity). stratified analysis based on ethnicity showed effect Caucasians TT. Conclusions: Findings present suggest that 309 G allele might be associated reduced cancer. tumorigenesis influenced by sex hormonal status.
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