MDM2 SNP309 Accelerates colorectal tumour formation in women

作者: G. L Bond , C. Menin , R. Bertorelle , P. Alhopuro , L. A Aaltonen

DOI: 10.1136/JMG.2006.043539

关键词:

摘要: Recent studies have shown that the G-allele of MDM2 SNP309 (T/G) in p53 tumour suppressor pathway can accelerate tumorigenesis and alter risk various cancers women not men. In this report, data are presented from two independent groups patients suggest accelerates colorectal formation only women, lend further support to model primarily female-specific hormones, such as oestrogen, could either directly or indirectly allow for women.

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