DNA Lesions, DNA Repair, and Chromosomal Aberrations
作者： A. T. Natarajan , R. C. Vyas , F. Darroudi , L. H. F. Mullenders , M. Z. Zdzienicka
DOI: 10.1007/978-3-642-75682-5_4
关键词: DNA 、 Premature chromosome condensation 、 Chromatid 、 Restriction enzyme 、 Genome instability 、 Endonuclease 、 Molecular biology 、 Biology 、 Sister chromatid exchange 、 DNA repair
摘要: Among the DNA lesions induced by ionizing radiations, double-strand breaks (DSBs) appear to be most important, leading chromosomal aberrations and cell death. We have presented biochemical cytological evidence for this conclusion. These include increase in frequeny of DSBs CHO cells X-irradiated posttreated with Neurospora endonuclease, an enzyme which specifically cuts single-stranded DNA, thus generating (Natarajan Obe 1978; Natarajan et al. 1980). In addition, restriction endonucleases, induce only one type lesion, namely DSBs, a pattern similar that i.e., chromosome G1 chromatid following G2 treatment 1984, Winkel 1985).
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