Gamma-Ray-Induced Cell Killing and Chromosome Abnormalities in the Bone Marrow of p53-Deficient Mice
作者： L. Wang , Y. Cui , B. I. Lord , S. A. Roberts , C. S. Potten
DOI: 10.2307/3579455
关键词: Bone marrow 、 Lymphocyte 、 Haematopoiesis 、 Biology 、 Stem cell 、 Molecular biology 、 Radiosensitivity 、 Cell cycle 、 Cell type 、 Cell killing 、 Immunology
摘要: Resistance to the lethal effects of ionizing radiation has been demonstrated in a wide variety cell types with defects p53 gene (thymocytes, splenic B and T cells, vitro hemopoietic colony-forming cells intestinal mouse, embryo rat, human Burkitt's lymphoma cells). In contrast, Slichenmeyer et al. (Cancer Res. 53, 4164-4167, 1993) found no evidence resistance fibroblasts derived from null mice. The aim our study was compare response (in CFC) fibroblastoid or units (CFU-F) within same tissue (marrow) mice (-/-), heterozygotes (+/-) wild-type animals (+/+). We have also tested hypothesis that, proliferating radiation-induced killing is mediated through chromosome damage by examining relationship between these end points three mouse types. Both CFC CFU-F -/- were resistant ...
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