Regional hemodynamic effects of nociceptin/orphanin FQ in the anesthetized rat
作者： Aly M Abdelrahman , Catherine C.Y Pang
DOI: 10.1016/S0014-2999(02)02154-4
关键词: Endocrinology 、 Medicine 、 Endogenous opioid 、 Dilator 、 Mean arterial pressure 、 Vasodilation 、 Skeletal muscle 、 Nociceptin receptor 、 Internal medicine 、 Vascular resistance 、 Hemodynamics
摘要: Abstract This study examined the vasodilator action of nociceptin, an endogenous opioid receptor-like ligand (ORL1), in thiobutabarbital-anesthetized rats, via triple-isotope microspheres technique. Nociceptin (10, 30 nmol/kg, left ventricular injection) reduced mean arterial pressure (−27, −29 mm Hg), total peripheral resistance (−36, −41% baseline) and heart rate (−8, −11% baseline), but did not significantly affect cardiac output. The vehicle (0.9% NaCl) alter hemodynamics. Both doses nociceptin caused similar changes flow conductance all tissues. increased flows to skeletal muscle, slightly caecum colon, other organs With normalized by reflect intrinsic vascular tone, was found increase tissues, except for intestine, spleen, colon. Its dilator influence greater muscle (≈250% baseline conductance) than lungs, heart, liver, stomach, kidneys, skin, testes brain (140–160% baseline). Thus, causes generalized vasodilatation; its greatest is on bed.
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