Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat.
作者： H.C. Champion , M.A. Czapla , P.J. Kadowitz
DOI: 10.1016/S0196-9781(97)00003-X
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摘要: Abstract Champion, H. C., M. A. Czapla and P. J. Kadowitz. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output total peripheral resistance in rat. Peptides 18 (5) 72–732, 1997.—The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered opioid-like G-protein coupled ORL1. In present study, responses to intravenous injections of nociceptin were investigated systemic vascular bed Nociceptin induced dose-related arterial pressure when injected doses 1–30 nmol/kg IV. decreased heart rate 10 30 IV, significantly output. terms relative vasodilator activity, was approximately 10-fold less potent than beta-adrenergic receptor agonist isoproterenol. These data show that has novel activity
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