Upper Motor Neurone Syndrome and Spasticity: Neurophysiology of spasticity

作者: Geoff Sheean

DOI: 10.1017/CBO9780511544866.003

关键词: SpasticityStretch reflexMuscle contractureClonusNeuroscienceHypertoniaSpinal shockMuscle toneMedicineReciprocal inhibition

摘要: The pathophysiology of spasticity is a complex subject and one frequently avoided by clinicians. Spasticity the other features, positive negative, upper motor neurone (UMN) syndrome arise from disruption certain descending pathways involved in control. Hyperexcitability spinal reflexes forms basis most clinical signs UMN syndrome, which have common excessive muscle activity. These may be divided into two groups, proprioceptive nociceptive/cutaneous reflexes. clasp-knife phenomenon combines features both at least lower limbs. Contractures are well known feared complication reducing range motion joint. There has been recent investigation relationship between stretch reflex hyper excitability contractures. does not appear to exist contracting agonists would really interfere with movement.

参考文章(194)
Yasuhiro Kagamihara, Akito Hayashi, Yasuyuki Okuma, Masanori Nagaoka, Yasoichi Nakajima, Reisaku Tanaka, Reassessment of H-reflex recovery curve using the double stimulation procedure. Muscle & Nerve. ,vol. 21, pp. 352- 360 ,(1998) , 10.1002/(SICI)1097-4598(199803)21:3<352::AID-MUS9>3.0.CO;2-9
Blair Calancie, James G. Broton, K. John Klose, Monique Traad, John Difini, D. Ram Ayyar, Evidence that alterations in presynaptic inhibition contribute to segmental hypo- and hyperexcitability after spinal cord injury in man. Electroencephalography and Clinical Neurophysiology. ,vol. 89, pp. 177- 186 ,(1993) , 10.1016/0168-5597(93)90131-8
Richard B. Stein, Presynaptic inhibition in humans. Progress in Neurobiology. ,vol. 47, pp. 533- 544 ,(1995) , 10.1016/0301-0082(95)00036-4
A. Rossi, B. Decchi, V. Vecchione, Supraspinal influences on recurrent inhibition in humans. Paralysis of descending control of Renshaw cells in patients with mental retardation Electroencephalography and Clinical Neurophysiology. ,vol. 85, pp. 419- 424 ,(1992) , 10.1016/0168-5597(92)90056-H
S. J. Fung, O. Pompeiano, C. D. Barnes, Coerulospinal influence on recurrent inhibition of spinal motonuclei innervating antagonistic hindleg muscles of the cat. Pflügers Archiv: European Journal of Physiology. ,vol. 412, pp. 346- 353 ,(1988) , 10.1007/BF01907550
E.D. Schomburg, Spinal sensorimotor systems and their supraspinal control Neuroscience Research. ,vol. 7, pp. 265- 340 ,(1990) , 10.1016/0168-0102(90)90008-3
Gordon Boorman, Manuel Hulliger, Robert G. Lee, Kenji Tako, Reisaku Tanaka, Reciprocal Ia inhibition in patients with spinal spasticity. Neuroscience Letters. ,vol. 127, pp. 57- 60 ,(1991) , 10.1016/0304-3940(91)90894-Y
I. G. Milanov, Mechanisms of baclofen action on spasticity. Acta Neurologica Scandinavica. ,vol. 85, pp. 305- 310 ,(2009) , 10.1111/J.1600-0404.1992.TB04048.X
Thomas Elbert, Herta Flor, Niels Birbaumer, Stefan Knecht, Scott Hampson, Wolfgang Larbig, Edward Taub, Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury Neuroreport. ,vol. 5, pp. 2593- 2597 ,(1994) , 10.1097/00001756-199412000-00047