Growth and Development of Toxoplasma Gondii in Human Neurons and Astrocytes

摘要: Toxoplasma gondii (T. gondii) is one of the most common opportunistic infections affecting central nervous system (CNS) in AIDS patients. Disease results from a reactivation latent infection brain resulting severe and necrotizing encephalitis. In this study we infected primary culture human fetal with T. studied behavior both active stages system. We found that (tachyzoite) stage can infect astrocytes neurons. However, higher percentage were than Additionally, to support more replication did Both neurons also supported cyst stage, infections. These data indicate are host cells supporting reactivated infections, but cell types may be able evidence indicates cysts formed distinct neuronal cysts. findings have relevance