Carnitine Inhibits Hydrolysis of Inositol Phospholipids Induced by Activation of Metabotropic Receptors
作者： Marta Llansola , Vicente Felipo
关键词: Metabotropic glutamate receptor 6 、 Glutamate receptor 、 Biochemistry 、 G protein 、 Agonist 、 Biology 、 Metabotropic glutamate receptor 、 Metabotropic receptor 、 Metabotropic glutamate receptor 5 、 Carnitine
摘要: We previously found that carnitine prevents glutamate neurotoxicity and this effect is mediated by activation of metabotropic receptors. show now inhibits the hydrolysis inositol phospholipids induced different agonists receptors (tACPD; (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid; DHPG, (R,S)-3,5-dyhydroxyphenylglycine or S4C3HPG, (S)-4-carboxy-3-hydroxyphenylglycine). The EC50 was ca. 170 microM inhibition complete at 1 mM carnitine. Carnitine also completely arterenol (agonist adrenoceptors) only partially (ca. 50%) carbachol muscarinic receptors). did not inhibit phospholipase C activity but (43%) direct G proteins with AIF4-. results reported indicate likely interfering function some types proteins.
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