Autoantibodies to Survival of Motor Neuron (SMN) Complex
作者： Minoru Satoh , Jason Y.F. Chan , Angela Ceribelli , Edward K.L. Chan
DOI: 10.1016/B978-0-444-56378-1.00016-2
关键词: Immunofluorescence 、 SMN complex 、 Biology 、 Immunology 、 Cajal body 、 Survival of motor neuron 、 Nuclear dots 、 Autoantibody 、 Spinal muscular atrophy 、 snRNP
摘要: Autoantibodies to survival of motor neuron (SMN) complex immunoprecipitatean unusual set the Sm D-E-F-G proteins with four additional (130, 120, 38, and 33 kDa) but without other components (U1-70k, A, B′/B, C) small nuclear ribonucleoproteins (snRNPs, U1RNP, antigens). In immunofluorescence, all anti-SMN sera showed dots (Cajal body) cytoplasmic staining. Target antigens were identified as SMN (SMN, Gemin2, 3, 4) that plays a critical role in assembly snRNPs. All three patients initially white females polymyositis (PM), which seems interesting since deletion or mutation gene is known cause genetic neuromuscular disease, spinal muscular atrophy. addition, about 25% anti-snRNPs also had coexisting autoantibodies. Coexistence antibodies among anti-snRNPs-positive was associated features scleroderma PM less typical systemic lupus erythematosus.
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sci-hub.se 参考文章(10)
H B Richards, M Satoh, K J Hamilton, W H Reeves, Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins. Journal of Immunology. ,vol. 158, pp. 5017- 5025 ,(1997)
Suzie Lefebvre, Lydie Bürglen, Sophie Reboullet, Olivier Clermont, Philippe Burlet, Louis Viollet, Bernard Benichou, Corinne Cruaud, Philippe Millasseau, Massimo Zeviani, Denis Le Paslier, Jean Frézal, Daniel Cohen, Jean Weissenbach, Arnold Munnich, Judith Melki, Identification and characterization of a spinal muscular atrophy-determining gene Cell. ,vol. 80, pp. 155- 165 ,(1995) , 10.1016/0092-8674(95)90460-3
Jeongsik Yong, Lili Wan, Gideon Dreyfuss, Why do cells need an assembly machine for RNA-protein complexes? Trends in Cell Biology. ,vol. 14, pp. 226- 232 ,(2004) , 10.1016/J.TCB.2004.03.010
D.J. BATTLE, M. KASIM, J. YONG, F. LOTTI, C.-K. LAU, J. MOUAIKEL, Z. ZHANG, K. HAN, L. WAN, G. DREYFUSS, The SMN complex: an assembly machine for RNPs. Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 71, pp. 313- 320 ,(2006) , 10.1101/SQB.2006.71.001
L E Andrade, E K Chan, I Raska, C L Peebles, G Roos, E M Tan, Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. Journal of Experimental Medicine. ,vol. 173, pp. 1407- 1419 ,(1991) , 10.1084/JEM.173.6.1407
Minoru Satoh, Jason Y. F. Chan, Steven J. Ross, Angela Ceribelli, Ilaria Cavazzana, Franco Franceschini, Yi Li, Westley H. Reeves, Eric S. Sobel, Edward K. L. Chan, Autoantibodies to survival of motor neuron complex in patients with polymyositis: Immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins Arthritis & Rheumatism. ,vol. 63, pp. 1972- 1978 ,(2011) , 10.1002/ART.30349
Glenn E. Morris, The Cajal body. Biochimica et Biophysica Acta. ,vol. 1783, pp. 2108- 2115 ,(2008) , 10.1016/J.BBAMCR.2008.07.016
Sergey Paushkin, Amélie K Gubitz, Séverine Massenet, Gideon Dreyfuss, The SMN complex, an assemblyosome of ribonucleoproteins. Current Opinion in Cell Biology. ,vol. 14, pp. 305- 312 ,(2002) , 10.1016/S0955-0674(02)00332-0
Arthur H. M. Burghes, Christine E. Beattie, Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nature Reviews Neuroscience. ,vol. 10, pp. 597- 609 ,(2009) , 10.1038/NRN2670
Minoru Satoh, Marvin J. Fritzler, Edward K.L. Chan, Antihistone and Antispliceosome Antibodies Systemic Lupus Erythematosus (Fifth Edition). pp. 275- 292 ,(2011) , 10.1016/B978-0-12-374994-9.10016-6