Why do cells need an assembly machine for RNA-protein complexes?
作者： Jeongsik Yong , Lili Wan , Gideon Dreyfuss
DOI: 10.1016/J.TCB.2004.03.010
关键词:
摘要: Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small RNA (snRNA) and an extremely stable core of seven Sm proteins. The biogenesis pathway is complex, involving export snRNA, Sm-core assembly in the cytoplasm re-import mature snRNP. Although vitro cores assemble readily on uridine-rich RNAs, cells carried out by survival motor neurons (SMN) complex. SMN complex stringently scrutinizes RNAs specific features that define them as snRNAs identifies RNA-binding We discuss how this surveillance capacity might ensure only correct prevent illicit, potentially deleterious random RNAs.
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