Non-murine models to investigate tumor-immune interactions in head and neck cancer

摘要: The immune response has important roles in the biology of solid tumors, including oncogenesis, tumor growth, invasion and metastasis, to treatment. Improved understanding tumor-immune system interactions provided promising therapeutic options that are based on rescue enhancement anti-tumoral host response. Immune-based treatments have been approved for clinical use various types cancer, head neck cancer (HNC); other strategies involving combination therapies currently development. These novel were developed knowledge derived from vitro, silico, vivo pre-clinical studies. However, trials seldom replicate efficacy observed animal This lack correlation between studies may be related limitations models used; which highlights relevance considering immune-related aspects different models. Murine most frequently used HNC discussed elsewhere. Non-murine characteristics offer unique opportunities study etiology, strategies, interactions. current review focuses non-murine models, dog, cat, pig, zebrafish, frog, could investigate HNC.