Cholesterol in myelin biogenesis and hypomyelinating disorders.

作者: Gesine Saher , Sina Kristin Stumpf

DOI: 10.1016/J.BBALIP.2015.02.010

关键词: Niemann–Pick disease, type CCell biologyBiogenesisCentral nervous systemNeurodegenerationSmith–Lemli–Opitz syndromeBiologyMyelinOligodendrocyteBiochemistryPelizaeus–Merzbacher disease

摘要: The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

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