Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease
作者： Renata C. Pereira , Harald Jűppner , Carlos E. Azucena-Serrano , Ora Yadin , Isidro B. Salusky
DOI: 10.1016/J.BONE.2009.08.008
关键词: DMP1 、 Biology 、 Extracellular matrix 、 MEPE 、 Internal medicine 、 Endocrinology 、 Osteocyte 、 Osteoid 、 Renal osteodystrophy 、 Fibroblast growth factor 23 、 Bone remodeling
摘要: Fibroblast growth factor 23 (FGF-23), dentin matrix protein 1 (DMP1), and extracellular phosphoglycoprotein (MEPE) are skeletal proteins involved in the regulation of phosphate homeostasis bone metabolism. Circulating FGF-23 levels increased patients with chronic kidney disease (CKD); however, expression its by DMP1 MEPE have yet to be evaluated. Thus, these three was characterized immunohistochemistry 32 pediatric young adult CKD stages 2–5. When compared normal controls, were all CKD; significant differences not detected between pre-dialysis dialysis patients. Bone did differ from controls. expressed osteocyte cell bodies located at trabecular periphery. widely dendrites throughout bone. also bone, but only bodies. correlated directly plasma (r=0.43, p<0.01) (r=0.54, both inversely related osteoid accumulation. volume. In conclusion, mineralization. The patterns FGF-23, MEPE, markedly suggesting that individual osteocytes may specialized functions. Increases suggest function is altered early course CKD.
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