Bioactive composites fabricated by freezing‐thawing method for bone regeneration applications
作者： Maria Canillas , Gabriel G. de Lima , Miguel A. Rodríguez , Michael J. D. Nugent , Declan M. Devine
DOI: 10.1002/POLB.23974
关键词: Swelling 、 Composite material 、 Composite number 、 Bone regeneration 、 Polymer 、 Self-healing hydrogels 、 Materials science 、 Wollastonite 、 Ceramic 、 Buffer solution
摘要: Hydrogels are widely used for controlled delivery of therapeutic agents. However, hydrogels lack bioactivity to encourage bone formation and mechanical integrity. Moreover, chemically crosslinked exhibit cytotoxic effect. To overcome these limitations poly-vinyl alcohol (PVA) poly-acrylic acid (PAA) blends were combined with ceramic materials based on β tricalcium phosphate, wollastonite, magnesium silicate different pore size distributions. The final 3D matrix was physically using various freeze thawing (F/T) cycles. FTIR SEM analysis showed that ceramics dispersed within the polymer formed hydrogen bonds. Swelling studies in buffer solution pH 7.4 an increase swelling when added. Furthermore, rheological testing demonstrated incorporation caused properties which varies distributions grains DSC thermograms increased Tg values samples containing ceramics. Antimicrobial activity ciprofloxacin tested against a pathogen associated osteomyelitis presented positive results ciprofloxacin. combination strength ability encapsulate clinically relevant antimicrobial agent indicates composite this study has potential treatment osteomyelitis. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Phys. 2016, 54, 761–773
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