Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

摘要: Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions patients worldwide and an important cause chronic pain. Typical peripheral neuropathies are characterized by dysesthesias including numbness, crawling skin, a sensation "pins needles," burning stabbing In addition, can affect motor autonomic systems leading to symptoms such as weakness, constipation, dysregulation blood pressure. be either hereditary or acquired consequence diabetes treatment with chemotherapy agents. Many due degeneration long axons; however, mechanisms driving axon loss were unknown, so no therapies available preserve vulnerable axons prevent development neuropathy. With recent identification SARM1 injury-activated NADase enzyme that triggers degeneration, there now coherent picture emerging for mechanism axonal self-destruction. Here, we will present evidence inhibiting pathway neuropathy, describe mechanistic understanding program, discuss how these insights may translated clinic prevention other disorders.