Lysyl oxidase is essential for hypoxia-induced metastasis

摘要: Metastasis is a multistep process responsible for most cancer deaths, and it can be influenced by both the immediate microenvironment (cell-cell or cell-matrix interactions) extended tumour (for example vascularization). Hypoxia (low oxygen) clinically associated with metastasis poor patient outcome, although underlying processes remain unclear. Microarray studies have shown expression of lysyl oxidase (LOX) to elevated in hypoxic human cells. Paradoxically, LOX suppression progression, its role tumorigenesis seems dependent on cellular location, cell type transformation status. Here we show that regulated hypoxia-inducible factor (HIF) hypoxia breast head neck tumours. Patients high LOX-expressing tumours distant metastasis-free overall survivals. Inhibition eliminates mice orthotopically grown Mechanistically, secreted invasive properties cells through focal adhesion kinase activity matrix adhesion. Furthermore, may required create niche permissive metastatic growth. Our findings indicate essential hypoxia-induced good therapeutic target preventing treating metastases.