Metalated fluoropyridines and fluoroquinolines as reactive intermediates: new ways for their regioselective generation
作者： Guo-qiang Shi , Sadahito Takagishi , Manfred Schlosser
DOI: 10.1016/S0040-4020(01)80824-3
关键词: Reactive intermediate 、 Lithium diisopropylamide 、 Bicyclic molecule 、 Deprotonation 、 Organic chemistry 、 Reagent 、 Regioselectivity 、 Chemistry 、 Metalation 、 Superbase
摘要: The mixt. of lithium diisopropylamide and potassium tert-butoxide (LIDA-KOR reagent) is a powerful base which can be advantageously employed for the regioselective deprotonation fluoropyridines and, in particular, 3-fluoroquinoline. A novel cyclization process was elaborated prepn. latter product. [on SciFinder (R)]
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