Development and characterization of hydroxyapatite/β-TCP/chitosan composites for tissue engineering applications.
作者： Amin Shavandi , Alaa El-Din A Bekhit , M Azam Ali , Zhifa Sun , Maree Gould
DOI: 10.1016/J.MSEC.2015.07.004
关键词: Chitosan 、 Materials science 、 Ceramic 、 Composite material 、 Plasticizer 、 Porosity 、 Glycerol 、 Phosphate 、 Composite number 、 Biodegradation
摘要: Calcium phosphate ceramics that mimic bone composition provide interesting possibilities for the advancement in tissue engineering. The present study reports on a chitosan composite reinforced by hydroxyapatite (HA) and β-tricalcium (β-TCP) obtained from waste mussel shells cross-linked using tripolyphosphate (TPP). ratios of ceramic components composites were 20/10/70, 30/20/50 40/30/30 (HA/β-TCP/CH, w/w %). Biodegradation rate, structural properties in-vitro degradation bone-like scaffolds investigated. optimum amount TPP required was 2.5% glycerol used as plasticizer at an optimized concentration 1%. Tripolyphosphate developed freezing lyophilisation. Young's modulus increased 4kPa to 17kPa porosity dropped 85 68% increasing HA/β-TCP ratio. After 28days physiological solution, with higher ratio (e.g. 40/30/30) showed about 2% lower biodegradation comparison (i.e. 20/10/70). data suggest based could be potential candidates biomedical applications.
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