Effect of cisplatin on rat placenta development.

摘要: We examined the sequential histopathological changes in placenta from rats exposed to cisplatin. Cisplatin was intraperitoneally administered at 2 mg/kg/day during GDs 11-12 (GD11,12-treated group), or 13-14 (GD13,14-treated and placentas were sampled on 13, 15, 17 21. Fetal mortality rates increased up approximately 65% GD onward, fetal weights decreased 21 GD11,12-treated group. A reduction placental detected 15 macroscopically small thin both treated groups. Histopathologically, GD13,14-treated group, an increase apoptotic cells labyrinth zone, basal resulting zone hypoplasia. By contrast, experimental period zone. decrease Phospho-Histone H3 positive 13 hypoplasia of In addition, a marked glycogen cell-islands also 17. There interstitial invasion cell-like trophoblasts into metrial gland Therefore, we consider that cisplatin administration pregnant induces growth arrest leading placenta. It is assumed secondarily induced by failure cell island development associated with