Ovarian Cancer Relapse: Experimental Therapies

摘要: Epithe ovarian cancer has the highest mortality of all gynecologic cancers with an estimated 22,280 cases diagnosed in 2012 United States and 15,500 deaths [1]. For women between ages 60 79 years age, is fifth leading cause death following lung, breast, colorectal, pancreatic [2]. Survival improvements for newly have reached a plateau using upfront surgery followed by platinum- taxane-based chemotherapy. Thus, investigational efforts new therapeutic agents are underway effort to overcome chemotherapy-resistant ultimately improve survival. Insights into molecular biology through mechanisms such as The Cancer Genome Atlas Project identified potential targets Efficacy, toxicities, drug metabolism related targeted therapies elderly patient not available, thus, data on risk-benefit ratio this age group mainly derived from studies non-gynecologic cancers. This chapter reviews available management outlines application newer biologic patients recurrent cancer.