LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
作者： E A Rayl , K A Shackelford , L L Habeck , V F Patel , L G Mendelsohn
DOI:
关键词:
摘要: … N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-l-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based antifolate currently undergoing …
aacrjournals.org参考文章(38)
Barry Shane, Folylpolyglutamate Synthesis and Role in the Regulation of One-Carbon Metabolism Vitamins and Hormones Series. ,vol. 45, pp. 263- 335 ,(1989) , 10.1016/S0083-6729(08)60397-0
Elizabeth A. Rayl, Barbara A. Moroson, G. Peter Beardsley, The HumanpurH Gene Product, 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase Journal of Biological Chemistry. ,vol. 271, pp. 2225- 2233 ,(1996) , 10.1074/JBC.271.4.2225
10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates. Journal of Biological Chemistry. ,vol. 262, pp. 12519- 12525 ,(1987) , 10.1016/S0021-9258(18)45236-2
V J Davisson, W Sirawaraporn, D V Santi, Expression of human thymidylate synthase in Escherichia coli. Journal of Biological Chemistry. ,vol. 264, pp. 9145- 9148 ,(1989) , 10.1016/S0021-9258(18)60506-X
Dutschman Ge, Cheng Yc, Nanavathi Nt, Nair Mg, Starnes Mc, Fisher Mh, Activity of the New Antifolate N10-Propargyl-5,8-dideazafolate and Its Polyglutamates against Human Dihydrofolate Reductase, Human Thymidylate Synthetase, and KB Cells Containing Different Levels of Dihydrofolate Reductase Cancer Research. ,vol. 45, pp. 598- 600 ,(1985)
B A Moroson, G P Beardsley, R G Moran, E C Taylor, A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. Journal of Biological Chemistry. ,vol. 264, pp. 328- 333 ,(1989) , 10.1016/S0021-9258(17)31261-9
D.W. Fry, J.C. Yalowich, I.D. Goldman, Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. Journal of Biological Chemistry. ,vol. 257, pp. 1890- 1896 ,(1982) , 10.1016/S0021-9258(19)68121-4
Sirotnak Fm, Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer. Cancer Research. ,vol. 45, pp. 3992- 4000 ,(1985)
R G Moran, S W Baldwin, E C Taylor, C Shih, The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. Journal of Biological Chemistry. ,vol. 264, pp. 21047- 21051 ,(1989) , 10.1016/S0021-9258(19)30043-2
K.H. Dixon, T Mulligan, K.N. Chung, P.C. Elwood, K.H. Cowan, Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells Journal of Biological Chemistry. ,vol. 267, pp. 24140- 24147 ,(1992) , 10.1016/S0021-9258(18)35957-X