Mutant Plasmodium falciparum chloroquine resistance transporter in Hodeidah, Yemen: association with parasitologic indices and treatment-seeking behaviors.

摘要: Malaria still represents a major health problem in Yemen, particularly Hodeidah, despite continuing efforts to eliminate it. With the absence of clinically proven vaccines, chemotherapy with antimalarials is greatly needed. Chloroquine (CQ) has been popular as drug choice for malaria control. However, Plasmodium falciparum resistance CQ one main obstacles control and elimination. Although no longer recommended antimalarial chemotherapy, it remained number over-the-counter many endemic areas, including used self-medication. In addition, promising reports on efficacy reversal African countries brought again into scene. This led growing interest possibility its re-introduction, concerns raised about parasite artemisinin-based combination therapies. Therefore, present study aimed at analyzing CQ-associated pfcrt 76T mutation P. isolates from patients uncomplicated west Yemen. The association treatment-seeking behaviors use mutant allele was also studied. It revealed that there sustained high frequency this molecular marker among associated younger age, decreased density presence gametocytes blood. Delay seeking treatment frequent were significantly reporting history treatment.