摘要: Despite intensive research extending back to the 1930s, when first synthetic antimalarial drugs made their appearance, repertoire of clinically licensed formulations remains very limited. Moreover, widespread and increasing resistance these contributes enormously difficulties in controlling malaria, posing considerable intellectual, technical humanitarian challenges. A detailed understanding molecular mechanisms underlying agents is emerging that should permit new be rationally developed older ones engineered regain efficacy. This review summarizes recent progress analysing causes major its spread.
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