Microvascular Fluid Filtration and Lymph Formation

摘要: Pre-nodal lymph is the effluent of tissue interstitial fluid (ISF) and its flow equals net rate ISF formation. In most tissues, formed as an ultra-­filtrate plasma in capillaries venules microcirculation but some tissues composition dominated periodically (intestinal mucosa) or continuously (kidney) by absorbate from adjacent epithelia. As Starling argued 1896, microvascular filtration determined a balance hydrostatic osmotic pressures across pathways through endothelium experimental evidence supporting this concept reviewed. More recently, it has been appreciated that since filtration, steady state pressure differences endothelial are themselves dependent on them. This ensures formation continues even when low. Further, because ultrafiltration properties for macromolecules differ those main water small solutes, overall ultra-filter thought to be glycocalyx.