On lupus, vitamin D and leukopenia
作者： Juliana A. Simioni , Flavia Heimovski , Thelma L. Skare
DOI: 10.1016/J.RBRE.2015.08.008
关键词: Leukopenia 、 Vitamina d 、 Gynecology 、 Systemic lupus erythematosus 、 Medicine 、 Vitamin D and neurology
摘要: Introducao A regulacao imune esta entre os efeitos nao calcemicos da vitamina D. Assim, essa pode influenciar em doencas autoimunes, como o lupus eritematoso sistemico (LES). Objetivos Estudar a prevalencia deficiencia de D no LES e sua associacao com perfil clinico, sorologico tratamento, bem atividade doenca. Metodos Mensuraram‐se niveis sericos OH‐vitamina D3 153 pacientes 85 controles. Os dados sobre tratamento foram obtidos por meio revisao prontuarios. Simultaneamente determinacao D, foi feito um hemograma aplicado Sledai (SLE disease activity index [indice doenca LES]). Resultados tinham mais baixos do que controles (p = 0,03). Na analise univariada, serica esteve associada leucopenia 0,02) ao uso ciclofosfamida 0,007) metotrexato Foi verificada uma correlacao negativa dose prednisona 0,003). Nao encontrada medida pelo 0,88). Em estudo regressao multipla, somente permaneceu independente (B 4,04; p 0,02). Tambem nivel serico granulocitos 0,01), mas contagem linfocitos 0,33). Conclusao tem Essa doenca, (granulocitopenia).
core.ac.uk
sci-hub.se 参考文章(27)
He Z, Hu Z, Xiong J, Zhang Y, Zeng X, Association of vitamin D receptor gene polymorphisms with systemic lupus erythematosus: a meta-analysis. Clinical and Experimental Rheumatology. ,vol. 32, pp. 174- ,(2014)
Michelle Petri, Kayode J. Bello, Hong Fang, Laurence S. Magder, Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis & Rheumatism. ,vol. 65, pp. 1865- 1871 ,(2013) , 10.1002/ART.37953
D A Bell, K P White, J W Bijlsma, A M Huisman, R Vieth, A Algra, M Harth, J W Jacobs, Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. The Journal of Rheumatology. ,vol. 28, pp. 2535- 2539 ,(2001)
Thomas Herzinger, Gerd Plewig, Martin Röcken, Use of sunscreens to protect against ultraviolet-induced lupus erythematosus. Arthritis & Rheumatism. ,vol. 50, pp. 3045- 3046 ,(2004) , 10.1002/ART.20426
MID Souto, A Coelho, C Guo, LMC Mendonça, S Argolo, JAS Papi, MLF Farias, Vitamin D insufficiency in Brazilian patients with SLE: prevalence, associated factors, and relationship with activity: Lupus. ,vol. 20, pp. 1019- 1026 ,(2011) , 10.1177/0961203311401457
J Bogaczewicz, A Sysa-Jedrzejowska, C Arkuszewska, J Zabek, E Kontny, DP McCauliffe, A Wozniacka, Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters Lupus. ,vol. 21, pp. 477- 484 ,(2012) , 10.1177/0961203311427549
Donald M. McCarthy, Jesus F. San Miguel, Hedley C. Freake, Philip M. Green, Heddy Zola, Daniel Catovsky, John M. Goldman, 1,25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal human bone marrow cells Leukemia Research. ,vol. 7, pp. 51- 55 ,(1983) , 10.1016/0145-2126(83)90057-7
A Danza, G Ruiz-Irastorza, Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies: Lupus. ,vol. 22, pp. 1286- 1294 ,(2013) , 10.1177/0961203313493032
Rasha T Hamza, Khaled S Awwad, Mohamed K Ali, Amira I Hamed, None, Reduced serum concentrations of 25-hydroxy vitamin D in Egyptian patients with systemic lupus erythematosus: relation to disease activity. Medical Science Monitor. ,vol. 17, ,(2011) , 10.12659/MSM.882131
Adrianna Mostowska, Margarita Lianeri, Mariusz Wudarski, Marzena Olesińska, Paweł P. Jagodziński, Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus Molecular Biology Reports. ,vol. 40, pp. 803- 810 ,(2013) , 10.1007/S11033-012-2118-6