System and methods for qualitatively and quantitatively comparing complex admixtures using single ion chromatograms derived from spectroscopic analysis of such admixtures

摘要: System for analyzing a protein sample, comprising reactor vessel, chromatographic column, mass spectrometer, and computer system. The vessel comprises an enzyme activity capable of digesting the sample in order to provide plurality peptide digests, inlet port receiving be digested, exit discharging digests. column medium chromatographically fractionating digests as are eluted through wherein said being flow communication with effluent fractionated spectrometer is generating spectroscopic data set from which first selective ion chromatograms can generated. has column. system operationally coupled such that set. programming enabling analyze samples using derived