Effects of Intensive BP Control in CKD

摘要: The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes participants baseline the Systolic Blood Pressure Intervention Trial. randomly assigned to a systolic <120 mm Hg (intensive group; n=1330) or <140 (standard n=1316). After median follow-up 3.3 years, primary composite cardiovascular outcome occurred 112 intensive group 131 standard (hazard ratio [HR], 0.81; 95% confidence interval [95% CI], 0.63 1.05). also had lower rate all-cause death (HR, 0.72; CI, 0.53 0.99). Treatment effects did not differ between without (P values interactions ≥0.30). main kidney outcome, defined as ≥50% decrease eGFR from ESRD, 15 16 0.90; 0.44 1.83). initial 6 months, slightly higher change (-0.47 versus -0.32 ml/min per 1.73 m2 year; P<0.03). overall serious adverse events treatment groups, although some specific more often group. Thus, among diabetes, targeting an SBP<120 compared reduced rates major evidence effect modifications by deleterious on outcome.