Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles

摘要: The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the drug development process. Following oral administration, with rates generally show erratic and incomplete absorption which may lead to therapeutic failure. aim of this study was improve subsequently bioavailability model drug. Microparticles containing (griseofulvin) were produced spray drying absence/presence hydrophilic surfactant. Poloxamer 407 chosen as surfactant particle wetting hence rate. dried particles characterized vitro studies vivo carried out. results obtained showed that absolute griseofulvin/Poloxamer significantly increased compared control. Although griseofulvin alone drug's rate, no significant improvement seen when Therefore, it believed better characteristics conferred responsible for enhanced