Dissolution of ibuprofen from spray dried and spray chilled particles.
作者： Ebtessam A Essa , Amal A. Elkordy
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摘要: The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, dissolution and wetting these drugs. Consequently, the aim this study was improve a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying chilling technology in absence/presence hydrophilic surfactant. Poloxamer 127, triblock copolymer, chosen as surfactant particle wettability hence rate. prepared formulations evaluated vitro intrinsic solubility. In addition, particles characterised scanning electron microscopy (SEM), differential calorimeter (DSC) Fourier transform infrared spectroscopy (FT-IR). SEM revealed changes surface morphology processed ibuprofen, suggesting effective formation particles. DSC data showed shifting melting peak towards lower temperature particles, indicating possibility /polymer interaction. results studies dried ibuprofen/Poloxamer 127 significantly (P< 0.05) increased percentage release compared control (ibuprofen raw material). For chilling, did not even less than that control. FTIR demonstrated reduced crystallinity, but chilled there evidence polymorphic with without it believed useful tool wettability, solubility behaviour drugs, contrast technique.
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