Novel techniques for solubility, dissolution rate and bioavailability enhancement of class II and IV drugs

摘要: Enhancement of solubility, dissolution rate and bioavailability drug is a very challenging task in development, nearly 40% the new chemical entities currently being discovered are poorly water soluble drugs. The solubility properties drugs play an important role process formulation development. Among all newly most lipophilic fail to reach market due their poor solubility. ability deliver will grow significance coming years as NCEs relied upon for larger share revenue within pharmaceutical by innovator companies. Similarly, generic manufacturers need employ economically efficient methods delivery more low go off patent, order maintain competitive edge sufficiently compete profit margins shrink this price-sensitive industry.