Comparison of Anti-Epileptic Drug Levels in Different Cases of Sudden Death

摘要: Sudden unexplained death syndrome (SUDS) in epilepsy is identified as an epileptic individual with no anatomic cause found at autopsy. SUDS appears to be associated subtherapeutic levels of anticonvulsants. demonstrable autopsy accounts for 5% 30% deaths individuals. In the majority cases, however, individuals can demonstrated We examined anti-epileptic drug concentrations decedents who died a direct result and compared these findings those from control population patients suddenly due some unrelated cause. This retrospective study was conducted on all involving Jefferson County Coroner/Medical Examiner office 1986–95. Out 115 total cases underlying 60 cases—52 8 caused by accident precipitated seizure. 44 decedent's epilepsy. 11 contribution could not determined. Published articles report medication 63% 94% cases. 69% 52 SUDS, 75% where seizure causing death, 34% population. The incidence anticonvulsants significantly greater dying their than