Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

作者: A. M. Reynolds , M. D. Holmes , S. M. Danilov , P. N. Reynolds

DOI: 10.1183/09031936.00187310

关键词: Bone morphogenetic protein receptorRight ventricular hypertrophyVascular resistancePulmonary hypertensionHypoxia (medical)EndocrinologyBMPR2Cancer researchGene deliveryInternal medicineVascular remodelling in the embryoMedicine

摘要: … Values are calculated as the ratio of chemiluminescence of the respective BMPR2 signal over … Our results show that BMP-2 and BMP-7 lead to a reversal of EndMT even in the ongoing …

参考文章(51)
Sergei M. Danilov, Vitaly D. Gavrilyuk, Folker E. Franke, Katarina Pauls, David W. Harshaw, Timothy D. McDonald, David J. Miletich, Vladimir R. Muzykantov, Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 280, ,(2001) , 10.1152/AJPLUNG.2001.280.6.L1335
SYLKE HASSEL, SIMONE SCHMITT, ANKE HARTUNG, MARTIN ROTH, ANJA NOHE, NILS PETERSEN, MARCELO EHRLICH, YOAV I. HENIS, WALTER SEBALD, PETRA KNAUS, Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes. Journal of Bone and Joint Surgery, American Volume. ,vol. 85, pp. 44- 51 ,(2003) , 10.2106/00004623-200300003-00009
Paul N. Reynolds, Stuart A. Nicklin, Lioudmila Kaliberova, Brian G. Boatman, William E. Grizzle, Irina V. Balyasnikova, Andrew H. Baker, Sergei M. Danilov, David T. Curiel, Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo Nature Biotechnology. ,vol. 19, pp. 838- 842 ,(2001) , 10.1038/NBT0901-838
Kirk B Lane, Rajiv D Machado, Michael W Pauciulo, Jennifer R Thomson, John A Phillips, James E Loyd, William C Nichols, Richard C Trembath, None, Heterozygous germline mutations in BMPR2 , encoding a TGF-β receptor, cause familial primary pulmonary hypertension Nature Genetics. ,vol. 26, pp. 81- 84 ,(2000) , 10.1038/79226
Terence D Allen, Ana M Schor, Andrew B Sutton, E Arciniegas, Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro Journal of Cell Science. ,vol. 103, pp. 521- 529 ,(1992)
Azusa Kitao, Yasunori Sato, Seiko Sawada-Kitamura, Kenichi Harada, Motoko Sasaki, Hiroyasu Morikawa, Susumu Shiomi, Masao Honda, Osamu Matsui, Yasuni Nakanuma, Endothelial to Mesenchymal Transition via Transforming Growth Factor-β1/Smad Activation Is Associated with Portal Venous Stenosis in Idiopathic Portal Hypertension American Journal of Pathology. ,vol. 175, pp. 616- 626 ,(2009) , 10.2353/AJPATH.2009.081061
Matthew Thomas, Cerys Docx, Alan M Holmes, Sarah Beach, Nicholas Duggan, Karen England, Catherine Leblanc, Clemence Lebret, Francis Schindler, Farheen Raza, Christoph Walker, Alexi Crosby, Rachel J Davies, Nicholas W Morrell, David C Budd, None, Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline The American Journal of Pathology. ,vol. 174, pp. 380- 389 ,(2009) , 10.2353/AJPATH.2009.080565
Raymond L. Benza, Dave P. Miller, Mardi Gomberg-Maitland, Robert P. Frantz, Aimee J. Foreman, Christopher S. Coffey, Adaani Frost, Robyn J. Barst, David B. Badesch, C. Gregory Elliott, Theodore G. Liou, Michael D. McGoon, Predicting Survival in Pulmonary Arterial Hypertension Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) Circulation. ,vol. 122, pp. 164- 172 ,(2010) , 10.1161/CIRCULATIONAHA.109.898122
Danielle L. Burke, Maria G. Frid, Claudia L. Kunrath, Vijaya Karoor, Adil Anwar, Brandie D. Wagner, Derek Strassheim, Kurt R. Stenmark, Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 297, ,(2009) , 10.1152/AJPLUNG.90591.2008
Rory E. Morty, Bozena Nejman, Grazyna Kwapiszewska, Matthias Hecker, Anka Zakrzewicz, Fotini M. Kouri, Dorothea M. Peters, Rio Dumitrascu, Werner Seeger, Petra Knaus, Ralph T. Schermuly, Oliver Eickelberg, Dysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 27, pp. 1072- 1078 ,(2007) , 10.1161/ATVBAHA.107.141200