Investigative Therapies in Pulmonary Arterial Hypertension

摘要: Pulmonary arterial hypertension (PAH) remains a serious, life threatening disease of unclear etiology. Despite the rapid development numerous drugs to treat disease, no cure is presently available. New treatments for PAH that are able reverse abnormal pulmonary vascular remodeling responsible much this badly needed. To accomplish goal, novel therapies target many dysfunctional pathways have been identified in will need be developed. This chapter reviews known alterations gene expressions, vasoconstriction, inflammation, metabolism, and cellular proliferation pathogenesis PAH. Potential pharmacologic targets arising from these abnormalities reviewed along with data, where available, animal studies small clinical trials attempted through manipulation pathways.