MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension.
作者： Ke Yuan , Mark Orcholski , Xuefei Tian , Xiaobo Liao , Vinicio A de Jesus Perez
DOI: 10.1517/14728222.2013.765863
关键词:
摘要: Introduction: MicroRNAs (miRNAs) are small noncoding RNAs that not only regulate gene expression during normal development but can also be active players in several diseases. To date, studies have demonstrated a possible role for specific miRNAs the regulation of pulmonary vascular homeostasis suggesting novel therapeutic agents which target these modulators could serve to treat arterial hypertension (PAH). Areas covered: The characterization miRNA-mediated modulation circulation is expanding very rapidly. This review summarizes current relevant findings on pathogenesis PAH and expands potential use molecules as future disease-modifying therapies. Expert opinion: Further understanding miRNA biology function will further enhance our their contribution PAH. implementation systems bio...
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