A framework for detecting and characterizing genetic background-dependent imprinting effects

摘要: Genomic imprinting, where the effects of alleles depend on their parent-of-origin, can be an important component genetic architecture complex traits. Although there has been a rapidly increasing number studies that have examined imprinting effects, none whether background. Such are critical for evolution genomic because they allow state locus to evolve as function Here we develop two-locus model epistasis includes epistatic interactions involving and apply this scan mouse genome loci modulate quantitative trait (QTL). The inclusion leads nine orthogonal forms epistasis, five which do not appear in usual decomposition epistasis. Each form represents change status one across different classes genotypes at other locus. Our identified two pairs show patterns effect changes backgrounds Thus, our provides framework detection background-dependent should provide insights into background dependence imprinting. application supports assertion by identifying reciprocal provided changes.